In this cohort of euthyroid adults at high CV risk (hypertension and dyslipidemia), our key findings were as follows: upper-normal TSH (>2.16 mIU/L) was associated with significantly higher TG and Tg/HDL ratios, suggesting heightened insulin resistance; lower-normal TSH (0.5-2.16 mIU/L) was independently associated with a fivefold increased risk of stroke, even though these patients did not display marked differences in blood pressure, fasting glucose, or lipid parameters (beyond Tg). The gene discussed is TG; the disease is stroke disorder.