Among the IGPs enriched in the IIM-ILD group, IgG2-N4H3F1 correlated positively with muscle weakness (r = 0.23, p = 0.036), CRP (r = 0.36, p = 0.001), and LDH (r = 0.30, p = 0.006), and inversely with anti-MDA5 antibody positivity (r = -0.27, p = 0.015). Here, CRP is linked to interstitial lung disease.