Across multiple tumor types, NSUN2 acts as a positive regulator of tumor progression by stabilizing target RNAs through m5C methylation, enhancing RNA stability, translation efficiency, and splicing, and activating oncogenic signaling pathways (e.g., Ras/PI3K–AKT/ERK, β-catenin, STAT3). Here, NSUN2 is linked to neoplasm.