KSR1 and colorectal carcinoma: Mechanistic studies show that LINC02167 functions as a molecular scaffold, forming a complex with YBX1 and ILF3, which facilitates YBX1 recognition and binding of NSUN2-mediated m5C modification sites on KSR1 mRNA, thereby stabilizing KSR1 mRNA and activating the ERK/MAPK signaling pathway to drive CRC metastasis (60).