The over-expression of SH3 domain binding protein 5 (SH3BP5) can inhibit the invasion ability of lung cancer cells, METTL3 can mediate m6A modification to promote its expression, and METTL3 itself also has the function of inhibiting the migration and invasion of lung cancer cells, thereby METTL3 can inhibit the deterioration of lung cancer (86). This evidence concerns the gene SH3BP5 and lung carcinoma.