In NSCLC, RBM15 up-regulates Kruppel-like factor 1 (KLF1), which suppresses the expression of TRIM13, a member of the tripartite motif (TRIM) family, and promotes ANXA8, a member of the annexin A (ANXA) family, thereby accelerating cancer progression (150). The gene discussed is KLF1; the disease is non-small cell lung carcinoma.