METTL14 and malignant colon neoplasm: In colon cancer, METTL14 targets SCD1, and its over-expression significantly enhances the m6A modification of SCD1 mRNA and reduces SCD1 mRNA levels, possibly through SCD1 mediated Wnt/β- Catenin signaling inhibits the stemness and metastasis of colon cancer cells, thereby hindering the tumorigenic process of colon cancer (103).