Previous ERAS studies in head and neck tumors could reduce CRP by about one-quarter (Nieminen et al., 2024; Ding et al., 2022) but did not simultaneously improve prealbumin; the present study shows that only by integrating probiotics with adequate nutritional input can the “micro-ecology–metabolism axis” achieve bidirectional modulation of the inflammation–nutrition imbalance. The gene discussed is CRP; the disease is head and neck neoplasm.