MRC1 and myocardial infarction: However, the expression of Mrc1 gene, a marker for M2 macrophages (Gordon and Martinez, 2010), was significantly increased compared to MI group without treatment, suggesting rEgAgB8/2 induces the transition of macrophages to the M2 phenotype, thereby exerting anti-inflammatory and reparative effects in the heart with MI (Figure 4B).