TNF and Alzheimer disease: Tiao Xin Fang (Sun et al., 2003) and Kai Xin San (Guo et al., 2019a; Guo et al., 2019b; Luo et al., 2020): They can inhibit the activation of MG; significantly reduce the expression of inflammatory cytokines, such as NF-κB, IL-1β, IL-6, IL-8, and TNF-α, in the brain tissue of AD animal models; decrease the expression level of the β-amyloid precursor protein; alleviate neuronal damage; and significantly improve the learning and memory ability of AD animal models.