In summary, while direct evidence implicating PRMT1 in the regulation of oxidative stress in NAFLD remains limited, insights from studies conducted in both ALD and NAFLD models indicate that PRMT1 may influence oxidative stress through multiple mechanisms, including the modulation of antioxidant gene expression and functional synergy with PGC‐1α. Here, PRMT1 is linked to metabolic dysfunction-associated steatotic liver disease.