For instance, CRC, PRMT1‐mediated methylation of metabolic enzymes like PGK1 and phosphoglycerate dehydrogenase (PHGDH) enhances glycolysis and serine synthesis, promotes the Warburg effect, and increases tumor stemness, thereby fostering a stress‐adaptive state conducive to resistance [72]. This evidence concerns the gene PHGDH and colorectal carcinoma.