Activation of the complement system (C3, C1q, Cfb, Cfd, C4b, C4a) and cytolytic effectors (Nitric oxide synthase, Lysozyme 2, Perforin and Gzmb) were also observed after vaccination in tumor and myeloid cells, together with up regulation of pattern recognition receptor (PRR) (RIG-1, CGAS-STING, MAVS) and cytokine profiles (Figure 4 F). Here, C3 is linked to neoplasm.