These neoantigen sequences, such as those arising from recurrent FS mutations in Ptprs and Igf2r, were predicted to encode epitopes that bind both MHC I and MHC II molecules and were shown to be expressed in untreated tumor cells, co-localizing with CD8+ T cell infiltration and cytotoxic markers, suggesting their in vivo immunogenicity. This evidence concerns the gene IGF2R and neoplasm.