Pathway enrichment using Enrichr (Reactome database) [16, 17] identified enrichment of differentially expressed proteins associated with AKT/mTOR signaling under Nrg1 treatment, receptor-tyrosine-kinase–related pathways and MAPK signaling for ET treatment, infection/immune-related pathways for AngII treatment, and developmental signaling and WNT signaling for IGF treatment (Figure 2C). This evidence concerns the gene NRG1 and infection.