TP53 and neoplasm: Two million CAL-27 cells were inoculated in Nu/J mice on each flank, and after two weeks, PBS, CPX-LNP, p53-LNP, and CPX/p53-LNP were intratumorally administered at 0.1 mg of mRNA per kg of body weight (mg/kg) four times over two weeks on each tumor (Figure 3G).