Transcriptome analysis of T cell functional states indicated that B7H3.BC CAR-T cells also exhibited reduced expression of exhaustion- and effector-associated genes and elevated expression of stemness markers such as KLF2, SELL (which encodes CD62L), and MYC compared to MGA271 and Hu8H9 CAR-T cells (Figure S8H). This evidence concerns the gene MYC and breast cancer.