Consistent with this, genetic ablation of core autophagy genes leads to the accumulation of ubiquitinated proteins and p62/SQSTM1-positive inclusions, oxidative stress, hepatomegaly, and hepatic steatosis, underscoring the role of autophagy in maintaining liver function (Komatsu et al., 2007, 2005; Ni et al., 2014). The gene discussed is SQSTM1; the disease is Hepatic steatosis.