MAPT and Alzheimer disease: These findings underscore the importance of considering personalized connectomic architecture to understand individual differences in tau distribution, building on fMRI-based evidence that patients with AD show individual-specific functional connectivity profiles (Millar et al., 2020; Stampacchia et al., 2024), with variability across networks such as the default mode, salience, and frontoparietal control (Adriaanse et al., 2014; Gour et al., 2014; Lehmann et al., 2015; Lin et al., 2018; Franzmeier et al., 2018; Tu et al., 2024).