Consistent with this, recent studies have begun to advocate for patient-tailored connectivity models to capture the heterogeneity of tau progression across individuals (Vogel et al., 2023; Tripathi et al., 2025), with evidence that clinical subtypes of AD, such as early- versus late-onset, show distinct patterns of both tau accumulation and functional connectivity (Schöll et al., 2017; La Joie et al., 2020; Lee et al., 2022; Franzmeier et al., 2018). The gene discussed is MAPT; the disease is Alzheimer disease.