Inter-individual variations in premorbid brain structure are thought to be a key contributor to variations in tau spread (Jacobs et al., 2018; Bocancea et al., 2023), a notion that is especially supported by an accumulating body of studies that report strong associations between the spatial structure of brain networks and the trajectory of tau spread in AD (Hoenig et al., 2018; Ossenkoppele et al., 2019; Franzmeier et al., 2020; Vogel et al., 2020). Here, MAPT is linked to Alzheimer disease.