Furthermore, comparison of differences in explained variances for other settings (e.g. hybrid FC minus on-target binding pattern) show that canonical patterns explain more variance in Aβ-PET than hybrid FC, especially in Aβ+ CN and patients with SCD or MCI (Fig. S10b–c), while the reverse is true for tau-PET. The gene discussed is MAPT; the disease is Schnyder corneal dystrophy.