In our ALS pre-symptomatic peripheral tissue TDP-43 pathology discovery cohort, we examined tissues from eight organ systems across 13 individuals for evidence of TDP-43 pathology using a TDP-43 RNA aptamer and a STMN-2 cryptic exon BaseScopeTM in situ hybridisation probe. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.