Moreover, the presence of TDP-43 pathology within the sebaceous glands is reminiscent of individuals with Parkinson’s disease, where pre-symptomatic α -synuclein pathology can be detected from sebum (83), and lipidomic analysis of skin swabs can differentiate people with Parkinson’s disease, Alzheimer’s disease, and healthy subjects (84). The gene discussed is TARDBP; the disease is early-onset autosomal dominant Alzheimer disease.