Indeed, skin pathology might provide insights in pathological protein aggregation beyond TDP-43, as indicated by a recent case-study instance of FUS protein nuclear loss detected from the a skin biopsy of an individual who presented with cramps and progressive limb weakness over a 2-year period, with a family history of progressive neuromuscular deterioration, whose FUS-ALS diagnosis was confirmed through the identification of a FUS-ALS associated (c.1562G>T; p. R521H) mutation (79). The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.