The first biopsy taken 24 months prior to ALS symptom onset showed no evidence of TDP-43 pathology, however, the second biopsy showed florid TDP-43 pathology within the dendritic cells of the dermis, the sebocytes within the sebaceous glands and within the peripheral nerve bundles surrounding the sebaceous glands. Here, TARDBP is linked to amyotrophic lateral sclerosis.