In our TDP-43 pre-symptomatic peripheral pathology discovery cohort, seven individuals had undergone skin biopsies prior to the onset of ALS motor symptoms - Pre-symptomatic TDP-43APT pathology was identified from skin in all seven individuals, ranging from 0.5–11 years (median 2 years; Q1-Q3 = 1–4 years; Figure 1B; Table 1) prior to symptom onset. This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.