Moreover, the presence of TDP-43 pathology within the sebaceous glands is reminiscent of individuals with Parkinson’s disease, where pre-symptomatic α -synuclein pathology can be detected from sebum (83), and lipidomic analysis of skin swabs can differentiate people with Parkinson’s disease, Alzheimer’s disease, and healthy subjects (84). This evidence concerns the gene TARDBP and Parkinson disease.