In the ALS cohort, this association was even stronger with 87% of the variation in TDP-43 pathology burden explained by ferritin levels (R2=0.867, p < 0.001; Figure 5A, Table 4), with a positive coefficient (β=0.875; Figure 5B, Table 4), demonstrating that amygdala ferritin levels explain a large proportion of TDP-43 pathology in ALS. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.