TARDBP and neurodegenerative disease: Amongst non-neurodegenerative disease brains examined, TDP-43 pathology was present in 31.6% (n=6/19; 95% CI 15.2–54.2) of individuals aged under 60 (the <60s cohort), and in 85.7% (n=12/14; 95% CI 58.8–97.2) of individuals greater than or equal to 60 years (the ≥60s cohort) (Figure 3A, Table 3).