In the AD cohort, amygdala ferritin levels were strongly associated with TDP-43 pathology, with 66% of the variation in TDP-43 pathology burden explained by ferritin levels (R2=0.664, p<0.01; Figure 5A, Table 4), with a slope coefficient of 1.764 (Figure 5B, Table 4) indicating that for each unit increase in ferritin levels, TDP-43 pathology burdens increase on average by over 1.7 units. This evidence concerns the gene TARDBP and Alzheimer disease.