Indeed, for ALS, this frontal cortex association of ferritin levels and TDP-43 pathology burden was stronger, with 81% of the variation in TDP-43 pathology burden explained by ferritin levels (R2=0.818, p < 0.001; Figure 5A, Table 4), with a positive coefficient (β=1.084; Figure 5B, Table 4) indicating a near 1:1 linear relationship between changes in ferritin and TDP-43 pathology. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.