To validate the predictive capabilities of our CS for unprofiled cellular contexts, we analyzed the CS of STL (a FOXM1 degrader, (20)) against independent RNA-seq data from Raghuwanshi et al. (21) profiling STL001, a chemical analog of STL, in two cell lines: FLO1 (esophageal adenocarcinoma) and OVCAR8 (ovarian carcinoma). The gene discussed is FOXM1; the disease is ovarian carcinoma.