DEFA6 and inflammatory bowel disease: Top gene ontology (GO) biological process (BP) terms implicated numerous DE genes (DEFA5, DEFA6, REG1A, REG1B, REG3A) with the formation of antimicrobial peptides, an important component of the adaptive immune response to pathogens and are also frequently overexpressed in IBD[76] (Supplementary Figure 5A).