Both G1330 and G8996 were significantly DE and correlated with the expression of their nearby protein-coding genes (L1TD1 and OLFM4 respectively); L1TD1 activates viral retrotransposition and OLFM4 promotes mucus secretion, both of which are processes that are aberrantly increased in active IBD [74], [75]. This evidence concerns the gene OLFM4 and inflammatory bowel disease.