To accomplish this, we utilized fresh endoscopically obtained gastric biopsies from BRCA1 and BRCA2 carriers without a history of GC as well as patient-derived gastric organoids (PDGOs) from both the gastric body and gastric antrum regions of the stomach and compared these to biopsies and PDGOs from individuals who do not harbor a BRCA1 or BRCA2 PGV (control). The gene discussed is BRCA1; the disease is gastric cancer.