One particular study that looked at the absolute risk of GC to age 80 in over 3,000 BRCA1 and over 2,000 BRCA2 families from across five continents found BRCA1 male and female carriers to have a 1.6% and 0.7% risk of GC, respectively, and both male and female BRCA2 carriers having a 3.5% risk of GC [9]. The gene discussed is BRCA2; the disease is gastric cancer.