In terms of clinical relevance, immunohistochemical analysis has shown that YAP1 expression is significantly associated with lymph node metastasis in CvSCC (Odds Ratio [OR]=3.62, 95% Confidence Interval [CI] 1.26–10.43) and is an independent prognostic factor for overall survival (Hazard Ratio [HR]=1.21, 95% CI 1.00–2.21, p=0.048) (87). The gene discussed is YAP1; the disease is metastatic malignant neoplasm in the lymph nodes.