In the endometrial cancer model, the level of MST2 cleavage correlates positively with HIF-1α expression, and MST inhibition attenuates HIF-1α-mediated transcriptional activity, suggesting that MST2 may indirectly influence Caspase-dependent apoptosis by modulating HIF-1α (228). The gene discussed is HIF1A; the disease is endometrial cancer.