Mechanistic studies have shown that the FUS-DDIT3-driven IGF-IR/PI3K/AKT signaling cascade promotes YAP1 stability and nuclear accumulation through dysregulation of the Hippo pathway, suggesting a synergistic relationship between YAP1 and FUS-DDIT3 in MLS progression (247). The gene discussed is IGF1R; the disease is McLeod neuroacanthocytosis syndrome.