Our previous study revealed that DSS can cause severe colon damage accompanied by decreased expression of PPARγ; activation of PPARγ via pioglitazone can effectively facilitate macrophages to switch from M1 to M2 phenotype via the STAT‐1/STAT‐6 pathway, which can alleviate the symptoms of IBD (Xue and Wu 2025). Here, PPARG is linked to inflammatory bowel disease.