CD274 and acute lymphoblastic leukemia: One such example is the work by Huang et al., who employed lentiviral‐mediated small hairpin RNA (shRNA) to silence PD‐L1 expression in acute lymphoblastic leukemia cells.[239] This genetic intervention led to a marked reduction of exosomal PD‐L1, thereby alleviating the immunosuppressive effects of leukemia‐derived exosomes (LEXs).