In murine models of melanoma, administration of NK‐92 cell‐derived EVs led to significant tumor regression, coinciding with FasL‐ and TNF‐α‐mediated induction of apoptosis in B16F10 cells.[273] Comparable effects have been observed in breast cancer models,[278] where paclitaxel‐loaded NK‐Exos enhanced apoptosis in MCF‐7 cells via upregulation of Bax and caspase‐3. Here, TNF is linked to neoplasm.