On the molecular level, TEX biogenesis is influenced by oncogenic mutations (e.g., KRAS, EGFR, p53), and tumor‐specific microenvironmental stressors such as hypoxia, acidosis, and inflammation.[219] Hypoxia‐inducible factor‐1α (HIF‐1α) upregulates key components of endosomal sorting complex required for transport (ESCRT) pathway (e.g., TSG101, CHMP4) and Rab GTPases (Rab27a/b), facilitating MVB maturation and EV release. The gene discussed is RAB27A; the disease is neoplasm.