CD47 and acute liver failure: In a mouse model of acute liver failure, Kim et al. engineered EVs to express SIRPα, a CD47‐binding ligand, enabling preferential accumulation in CD47‐overexpressing necroptotic hepatocytes.[180] These SIRPα‐EVs facilitated immune clearance of damaged cells via macrophage reprogramming and promoted hepatocyte regeneration, exemplifying the dynamic capacity of engineered EVs to reshape tissue microenvironments in vivo.