PRF1 and neoplasm: NK cell‐derived EVs (NK cell‐derived exosomes, NK‐Exos) have demonstrated distinct cytotoxic potential against malignancies, primarily through the vesicular delivery of NK‐specific effector proteins (Figure 2).[273] These EVs selectively incorporate and export perforin, granzyme B, FasL, and TRAIL—molecules that closely mirror the cytolytic arsenal of their parental NK cells and mediate direct apoptosis of diverse tumor targets via both intrinsic and extrinsic apoptotic pathways.[274, 275, 276, 277]