IL1B and neoplasm: NExos, particularly those derived from N1‐polarized neutrophils, have been reported to exert immunomodulatory effects by promoting macrophage activation and T cell proliferation through the transfer of proinflammatory mediators.[284] These NExos carry molecules such as IL‐1β, IL‐2, and IL‐4, which may contribute to shaping a more immunostimulatory tumor microenvironment.