In addition, normal chow‐fed DIO mice were also investigated and it was found that after 14 days, the mice SC injected with GIP/ICG@P/R8 NPs and followed by the NIR‐I laser irradiation also inhibited obesity development with a 23.48% weight reduction, in line with the previous examination. This evidence concerns the gene GIP and obesity due to melanocortin 4 receptor deficiency.