Misfolding, alteration of condensed phase and aggregation of more than 50 proteins is associated with cancer[26] and neurodegeneration,[24] including p53 (cancer),[5] Aβ/tau (Alzheimer's disease),[31, 32] α‐synuclein (Parkinson's disease),[33] prion proteins[34] (Creutzfeldt‐Jakob disease), fused in sarcoma (FUS, Amyotrophic lateral sclerosis, cancer),[35, 36] and huntingtin (Huntington's disease).[37] The nature of the aggregates related to cytotoxicity,[38] and the mechanisms by which they contribute to disease are still unclear. The gene discussed is HTT; the disease is Alzheimer disease.