For example, a 512 bp insertion (AFR AF=0.56; Non-AFR AF=0.02, Fst=0.65) was associated with expression changes in SHPK, a gene involved in sedoheptulokinase deficiency and broader metabolic regulation (Supplementary Fig. 9b–c, Supplementary Tables 1 and 5).77,78. This evidence concerns the gene SHPK and hyperinsulinemic hypoglycemia, familial, 4.