BID and osteoarthritis: Notably, our analysis revealed that the absence of an Alu element reduced BID expression and was associated with increased osteoarthritis risk in the AoU Phase 1 dataset (OR = 2.34, 95% CI = 1.00–5.50, P = 0.049), highlighting the potential regulatory impacts of Alu insertions on gene function and their relevance to trait association and disease susceptibility