These findings are consistent with those reported by Janus et al. (Janus et al., 2022), who investigated the role of heat shock transcription factor 1 in suppressing overactivation of stress response genes (ATF3, JUN, FOS) and pro-inflammatory cytokines (TNFα, IL-6) in non-cancerous and RKO CRC cells. Here, ATF3 is linked to colorectal carcinoma.