Notably, IL-6 expression was absent in two CRC cell lines harboring the BRAFV600E mutation, HT-29 and RKO, whereas it was detectable in the normal colon epithelial cell line CCD-841CoN and in the CRC cell line SW1116, characterized by low malignancy and lacking BRAF mutations (Ahmed et al., 2013). Here, IL6 is linked to colorectal carcinoma.