CXCL8 and neoplasm: Importantly, the dual downregulation of IL-6 and IL-8 by ECH147 suggests that this compound may exert broader anti-inflammatory and anti-tumour effects by modulating key pro-inflammatory cytokines and their associated signaling pathways or via long non-coding RNA (lncRNA)– microRNA (miRNA) networks that coordinate cytokine expression, as described by Xiao et al. (Xiao et al., 2020).