Finally, both of these associations, MS4A6A in Mic.13 and PPP1R37 in Mic.15 and Ast.5, were identified only by scTWAS and not detected by ZJ-TWAS or AG-TWAS, highlighting scTWAS’s ability to capture biologically meaningful and cell-state-specific signals in AD. This evidence concerns the gene PPP1R37 and Alzheimer disease.