This panel also included exonic regions of candidate oncogenes on chromosome 8q (15), NF1 (the key tumor suppressor frequently lost in NF1, secondarily in and PN and MPNST formation), additional genes implicated in MPNST transformation, and loci commonly mutated in clonal hematopoiesis of indeterminate potential (CHIP) (Supplementary Fig. 2). The gene discussed is NF1; the disease is malignant peripheral nerve sheath tumor.