In contrast, cfDNA from MPNST patients displayed diverse CNA profiles but with recurrent alterations affecting established tumor-associated regions, including frequent loss of established tumor suppressors (CDKN2A/B, TP53, and SUZ12), gain across chromosome 8q (e.g., MYC, RAD21, and TCEA1), and notable losses at MTAP and NF1. The gene discussed is CDKN2A; the disease is neoplasm.