We speculate that 1) female mice may exhibit greater baseline insulin sensitivity, potentially masking any mild effects of R. torques; 2) interactions between R. torques and host selenoproteins may counterbalance each other’s influence on type-2 diabetes pathogenesis; 3) the effects of R. torques on Se deficiency-induced type 2 diabetes may be age-dependent, becoming apparent only in middle-aged or older mice, but not in younger mice. Here, INS is linked to type 2 diabetes mellitus.