SOCS1 and Heart block: Eight displayed nominal significance (p < 0.05): one in AMR (RFXANK with macular degeneration), two in EUR (SEMA3E with heart block and STAT6 with hypothyroidism), and five in AFR (NOD2 with hepatitis, CLPB with lower gastrointestinal tract malignancies, SOCS1 with osteoporosis, and MAN2B2 with bronchus and lung cancer) (Supplementary Table 19).