The top three genes with the highest average CrF and GP for P+LP variants across eight genetic ancestry groups were: for CrF, CFTR (AR, cystic fibrosis, 1 in 16; 456 million individuals), G6PD (XLR, G6PD deficiency class I–favism, 1 in 20; 360 million), and DIAPH1 (AR, DIAPH1 deficiency, 1 in 32; 230 million); and for GP, NOD2 (AD, Blau syndrome, 1 in 47; 155 million), G6PD (XLR, G6PD deficiency class I–favism, 1 in 55; 135 million), and CFHR5 (AD/AR, factor H–related protein deficiency, 1 in 60; 123 million) (Supplementary Table 20). This evidence concerns the gene NOD2 and cystic fibrosis.