Similarly, Kdm8 knockdown in two other murine PDA cell lines (703T and 606T, both KrasG12D;Trp53flox/flox) greatly promoted ascites formation and metastatic burdens in the lungs and livers when transplanted orthotopically into the immunocompetent C57BL/6J mice (Figures 1K–1P and S1L–S1O). The gene discussed is KDM8; the disease is Patent ductus arteriosus.