However, genetic depletion of Hif1a, which encodes the hypoxia-stabilized subunit of the Hif1a/Arnt heterodimer, unexpectedly accelerated KrasG12D-driven pancreatic tumor progression and metastasis 22,23, suggesting that hypoxia may act through additional, Hif1-independent mechanisms. This evidence concerns the gene HIF1A and pancreatic neoplasm.