SLC6A4 and Cognitive impairment: For instance, SLC6A4 and the serotonin pathway were thought to be involved in the regulation of brain and auditory health through mood and social interaction (Fratelli et al., 2020); serotonin (5-HT), which is related to SLC6A4 function, may indirectly contribute to cognitive impairment while modulating psychosocial factors (Keesom and Hurley, 2020).