MAPT and Alzheimer disease: As the neurodegenerative disorder with the highest incidence rate (Livingston et al., 2020), AD is characterized by the extracellular oligomerization of β-amyloid (Aβ) into amyloid plaques and the intracellular hyperphosphorylation and aggregation of tau protein into neurofibrillary tangles (Hanseeuw et al., 2019; Table 2).