SYN1 and epilepsy: The genetic causes of ASD and epilepsy involve dysregulation of synaptic functions due to mutations in genes such as SYN1 (synapsin-1), SCN2A, and SCN8A (sodium voltage-gated channel alpha subunit 2 and 8), KCNQ2 and KCNQ5 (potassium voltage-gated channel subfamily Q member 2 and 5), SHANK3 (glutamate receptor signaling protein SH3 and multiple ankyrin repeat domains 3), GABRG2 or GABRG3 (gamma-aminobutyric acid type A receptor gamma subunits 2 and 3).