As a result, the VLW value remains high (the total VLW in affluent regions is 88 B US dollars), presenting a unique phenomenon of “high investment-high burden.” At the policy response level, South Korea has successfully increased the five-year success rate of hepatic carcinoma more than 40% by popularizing HBV screening and standardizing the ultrasound combined with AFP monitoring system (48), verifying the key role of the early screening policy in reducing the expense of advanced treatment. This evidence concerns the gene AFP and hepatocellular carcinoma.