(II) Minor: Monoclonal plasma cell proliferation (serum IgA/λ+, bone marrow cytological abnormalities); extravascular volume overload (ascites, pleural effusion, and edema); endocrinopathy (hypothyroidism and adrenal axis dysfunction); skin changes (hyperpigmentation); serum VEGF was normal but close to the upper limit of the reference range; and organomegaly (splenomegaly). This evidence concerns the gene CD79A and hypothyroidism.