The lysine demethylase KDM3A can demethylate p53-K372me1, inhibiting the tumor-suppressive functions of p53, which, in turn, down-regulates the expression of phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1) and p53 up-regulated modulator of apoptosis (PUMA), leading to tumor resistance to PTT [98]. This evidence concerns the gene BBC3 and neoplasm.