We found that CXCL1 lost its upregulatory effects on KEAP1 mRNA when FTO was knocked down, and the binding site mutation of KEAP1 mRNA also blocked the demethylation effects of FTO, suggesting that FTO is the crucial enzyme in promoting KEAP1 mRNA demethylation, and subsequently accelerates ROS burst, adipocyte lipolysis, and BC growth. This evidence concerns the gene CXCL1 and breast cancer.