After 30.7 ± 4.5 years of follow-up, 92.5% of adults negative for TPO-Abs at diabetes onset remained euthyroid, compared with only 5.6% of those who were positive (log-rank: χ2=131.5; 95% CI 3.92–8.09; p<0.001). This evidence concerns the gene TPO and diabetes mellitus.