CXCL8 and diabetes mellitus: In the skin, we noted an intriguing co-expression of mitotic regulators (e.g., CDK1, FOXM1) with a senescence-associated secretory phenotype (SASP), characterized by elevated IL1α/β and CXCL8. The accumulation of senescent keratinocytes has been implicated in persistent inflammation and delayed wound healing in both aging and diabetic skin (55).