A multicenter double-blinded RCT evaluated the effects of aspirin loading (325 mg orally) among patients with CAD who were on low-dose chronic aspirin therapy (100 mg daily) undergoing PCI compared to patients who didn’t receive the aspirin loading dose.10 Before PCI, the mean corrected thrombolysis in myocardial infarction frame count (cTFC) and cardiac troponin I (cTnI) were similar between the two groups. This evidence concerns the gene TNNI3 and myocardial infarction.