NPPB and cardiovascular disorder: B-Type Natriuretic Peptide (BNP) is released from ventricular myocytes due to myocardial stretching and is related to the extent of infarction and left ventricular dysfunction.43 Elevated BNP levels have been associated to poor neurocognitive functioning in community-dwelling older adults 44 and with stable cardiovascular disease.45 In our model, BNP shows greater predictive performance than left ventricular ejection fraction, another marker of heart efficiency and neurocognitive functioning, especially important when below 50%.