The glucokinase regulatory protein (GCKR) rs1260326 C>T (P446L) variant augments glucose‐driven de novo lipogenesis, and the membrane bound O‐acyltransferase domain‐containing 7 (MBOAT7) rs641738 C>T allele upsets phospholipid remodelling, both contributing to steatosis and inflammation [131, 132]. The gene discussed is GCKR; the disease is steatosis.