MAPT and Alzheimer disease: Surprisingly, tau nano-aggregates hyperphosphorylated at threonine 231 (p-T231) and threonine 181 (p-T181)are detected in control cases, whereas hyperphosphorylated serine 202/threonine 205 (p-S202/T205)nano-aggregates are specifically associated with AD and, to a lesser extent, observed in PART.