CATSPER2 and deafness-infertility syndrome: Among these rare diseases, deafness-infertility syndrome(DIS) is characterized by a CNV of chromosome 15q15.3, in loss (homozygous deletion) at the DFNB16 locus, involving the CATSPER2 and STRC genes; which is characterized by asthenotherozoospermia (males), and prelingual sensorineural hearing loss (both sexes) of mild to moderate intensity [7–9].