On the basis of known marker expression profiles, 14 distinct cell types were identified, including B- cells, CD4+T- cells, CD4+ Tregs, CD8+T- cells, dendritic cells, endothelial cells, fibroblasts, granulocytes, podoplanin-positive stromal cells (PPSCs), macrophages, myofibroblasts, plasma cells, tumor cells and marker-negative (“other”) cells (Fig. 1Band Suppl. This evidence concerns the gene CD4 and neoplasm.