CD4 and neoplasm: Similarly, in the tumor stroma interface (TSI), the tumor region bordering the tumor stroma presented significantly greater numbers of lymphocytes, including B- cells (mean cell fraction: 2.5% vs. 0.05%; p = 0.0002), CD4+T- cells (4.5% vs. 0.9%; p = 0.008), and CD8+T- cells (3.6% vs. 1.4%; p = 0.03).