Table S2B) revealed that the most differentially represented cell types and states (absolute cell state fraction ratios between HPV-positive and HPV-negative tumors greater than 1.5 and p < 0.05) in HPV-positive tumors were enriched for activated T- cell (ICOS+, CD44+, HLA-A+ and CD45RO+) and CD44+ B- cells across B- cell, CD4 T- cell, endothelial, fibroblast, plasma and tumor-immune enriched neighborhoods. This evidence concerns the gene ICOS and neoplasm.