CD4 and neoplasm: In HPV-positive tumors, the most enriched interactions included those between activated (CD44+) CD4 T- cells and CD79+ B- cells within the tumor–stroma interface (mean frequency of interaction of 0.88% HPV-positive vs. 0.04% HPV-negative; p = 0.0002), as well as interactions between tumor cells and immune populations, including CD4 T-cells, CD4 Tregs, dendritic cells, and macrophages (all p < 0.005).