Overexpression of SMIT1 promoted intracellular accumulation of myo-inositol, increased phosphoinositide levels (PIP2 and PIP3), while knockdown of SMIT1 yielded the opposite results in DLBCL-U2932 cells (Fig. 4A) and DLBCL-OCI-Ly10 cells (Fig. 4B). The gene discussed is SLC5A3; the disease is diffuse large B-cell lymphoma.