In CRC, MSC-derived EVs containing miR-34a-5p, which were generated through transfection of the hBM-MSCs with miR-34a-5p mimics, modulated the MYC proto-oncogene (c-MYC)/DNA methyltransferase 3a (DNMT3a)/ phosphatase and tensin homolog deleted on chromosome 10 (PTEN) axis to inhibit tumor growth and regulate epigenetic and proliferative pathways [39]. The gene discussed is MYC; the disease is colorectal carcinoma.