For example, in HNSCC, human bone marrow-derived MSCs (hBM-MSCs) transfected with miR-101-3p mimics produced EVs enriched with miR-101-3p, which effectively suppressed tumor progression by downregulating Collagen Type X Alpha 1(COL10A1) [37]. The gene discussed is COL10A1; the disease is head and neck squamous cell carcinoma.