For instance, IL-6 can promote the pro-tumor functions of neutrophils via STAT3 signaling, while IL-8 may induce NETs formation, thereby facilitating tumor metastasis [169, 174].Nevertheless, the precise concentration ranges of circulating IL-6 and IL-8 that predict immunotherapeutic outcomes require further delineation. The gene discussed is CXCL8; the disease is neoplasm.