A high intratumoral neutrophil burden in NSCLC showed a markedly suppressed T-cell response, evidenced by reduced expression of cytotoxic T-cell markers (CD8A, CD8B, GZMA, GZMB), lower infiltration of CD3+CD8+ T cells, and downregulation of IFN-γ-associated genes [58]. This evidence concerns the gene CD8A and non-small cell lung carcinoma.