BGLAP and osteoporosis: Furthermore, injecting exosomes isolated from healthy mouse skeletal muscle into BoNT/a-induced disuse osteoporotic mice significantly upregulates the expression of osteogenic markers such as Ocn(Osteocalcin) and Col-1 (Collagen Type I), improves the MAR(mineral apposition rate) in the distal femur, and mitigates bone loss caused by disuse osteoporosis.